Department
Department of Pharmacology
Pharmacology is the core subject of pharmacy and medical sciences, dealing with the research,
discovery, and
characterization of drugs which show biological effects and the elucidation of cellular function
in relation to
drugs. The subject involves elements of toxicology, biology, pharmaceutical chemistry,
biochemistry,
microbiology, biotechnology, physiology, and pathophysiology and is a broad scientific field
applicable to many
careers in the life sciences area. Pharmacology focuses more on the research aspect of this
pharmaceutical
science, teaching students to investigate the effects of chemical compounds and to innovate ways
of creating
remedies to disease conditions.
The two main areas of pharmacology are pharmacodynamics and
pharmacokinetics.
Pharmacodynamics deals with the effects of a drug on biological systems, and pharmacokinetics
studies the
effects of biological systems on a drug. In broad terms, pharmacodynamics discusses the drugs
with biological
receptors, and pharmacokinetics discusses the absorption, distribution, metabolism, and
excretion (ADME) of
drugs from the biological systems. Experimental pharmacology mainly deals with the drug
screening studies using
suitable animal models and isolated tissue preparations, including in vivo and in vitro studies.
Core Values
- Strive for excellence in clinical practice, research, innovation and teaching.
- Trust in teamwork, morality, autonomy, and fair-mindedness.
- Work with ethics, commitment, accountability, and professionalism.
- Perform duties with a student-centric attitude and mutual respect.
Goals
- Educate pharmacy students about the drug and its safety.
- Encourage graduate students to become independent researchers in pharmacology and
related fields.
- Undertake innovative research.
- Provide information and advice about existing and emerging drugs and toxic chemicals to
the institute and
public.
- Provide training to staff and the external community in pharmacology and toxicology.
- Train pharmacists in clinical practice.
Clinical Branches of Pharmacology
1. Clinical Branches
Clinical Pharmacology
The scientific study of drugs in humans, focusing on maximizing therapeutic benefits
and minimizing
adverse effects. It is a fast developing area in the medical field.
Pharmacotherapeutics
The study of using drugs to prevent, treat, or cure diseases.
Toxicology
The study of the adverse effects of chemicals and drugs on living organisms,
including the management of
poisoning.
Chemotherapy
The use of chemical agents (like antibiotics or anticancer drugs) to selectively
destroy invading
microorganisms or cancer cells.
2. Biological & Genetic Branches
Pharmacogenetics & Pharmacogenomics
The study of how an individual's genetic makeup affects their response to drugs,
which is essential for
personalized medicine.
Molecular Pharmacology
The study of how drugs interact at the molecular and cellular levels.
Neuropharmacology & Psychopharmacology
The study of how drugs affect the central nervous system, brain function, and
behaviour.
3. Natural, Formulation & Administrative Branches
Pharmacognosy
The study of crude drugs derived from natural sources, such as plants.
Pharmacy
The science and art of compounding, dispensing, and preparing medications for
administration.
Pharmacoepidemiology
The study of the effects and use of drugs across large human populations.
Pharmacoeconomics
The evaluation and comparison of the cost-effectiveness of different pharmaceutical
treatments.
Posology
The study of dosages and determining the right amount of a drug to administer.
Metrology
The study of weights and measures of drugs.
Clinical Pharmacology
Clinical pharmacology is essential for developing safe and effective drugs/therapies and for
achieving
regulatory approval. Clinical pharmacology studies aim to evaluate and understand a drug's
absorption,
distribution, metabolism, and excretion (ADME) properties, its pharmacodynamics — including both
desired effects
and adverse effects — and the impact of intrinsic factors (such as age, gender, weight,
race/ethnicity,
genetics/genomics, organ dysfunction, etc.) and extrinsic factors (such as food effect,
drug-drug interaction,
etc.).
Benefits of utilizing clinical pharmacology in drug development include:
- Optimizing dosing regimens for patients to obtain an optimum benefit/risk profile.
- Creating a better understanding of the safety and efficacy of drugs in special populations
(racial/ethnic
minorities, pregnant women, elderly, paediatrics, and patients with organ impairments).
- Evaluating the appropriateness of administering the drug with or without food.
- Determining the dosing schedules and body-weight dosing strategies based on the drug's PK
and safety
profile.
- Mitigating the risk to patients by better understanding possible drug-drug interactions
(DDI).
- Determining the likelihood of a drug prolonging the QTc interval at therapeutic doses or
under worst-case
scenarios.
- ADR monitoring and reporting.
Drug development involves sequential planned studies that include the
initial
preclinical phase followed by clinical studies in humans. A clinical pharmacologist can help
determine which
clinical studies are required to be conducted throughout the drug development process. Depending
on the drug,
some additional clinical pharmacology studies may be required, or some studies may be avoided
with the help of
pre-existing data and modelling tools.
Clinical Pharmacy
In the twenty-first century, clinical pharmacy has become one of the newest sub-specialities of
pharmacy. It is
here that pharmacists handle many facets of patient care, medicine delivery, and counselling
patients on the
responsible and safe use of medications. Clinical pharmacy is a branch of pharmacy where the
clinical pharmacist
gives patients care that maximises the use of their medications and encourages wellness, good
health and disease
prevention. Clinical pharmacy is defined as the use of drug control and the efficient use of
knowledge, ensuring
the highest level of safety in distribution and use of medicine through professional abilities
and ethics.
The new function of pharmacists in the twenty-first century is clinical pharmacy. It broadens the
scope of a
pharmacist's responsibilities beyond simple drug product distribution and control and good
manufacturing
standards. Additionally, it includes tasks required to fulfil a certain set of social
obligations relating to
the appropriate therapeutic use of drugs in areas like prescribing, dispensing, administering
medications,
recording professional services, involvement of the patient directly, examination of drug usage,
education,
consultation and counselling.
Practice of clinical pharmacy aims to ensure the patient's overall health to contribute
significantly to safe
and responsible use of medications. These objectives are designed to help the doctor to
prescribe and oversee
the patient's pharmacological therapy more effectively, and to assist the medical and
paramedical team in
facilitating efficient medication therapy. In order to maximise patient compliance with the drug
use process,
clinical pharmacy practice also addresses effective management of the documentation of
medication occurrences.
Duties & Responsibilities of a Clinical
Pharmacist
Although clinical pharmacists provide patient care across the board of healthcare facilities, the
clinical
pharmacy movement actually had its start in hospitals and clinics. They frequently work with
medical experts,
including doctors. Pharmacists should be fluent in common languages for easy and successful
communication with
patients and other professionals. A detailed understanding of disease's aetiology, signs,
symptoms,
pathophysiology, diagnostic procedures, pharmacokinetics, etc. is also demanded of pharmacists.
The clinical
pharmacist should receive appropriate clinical training in order to provide information about
sensible drug
usage, drug therapy and drug dosages. Clinical pharmacists take grand rounds, IP and OP clinical
rounds,
monitoring drug interactions, ADR monitoring and reporting, etc. in hospitals.
Assortment of Patient Information
Recognisable Proof of Issues
Laying Out Result Objectives
Grand Rounds
IP & OP Clinical Rounds
Drug Interaction Monitoring
ADR Monitoring & Reporting